404 The Vps33b-Vipar complex is required for epidermal homeostasis
نویسندگان
چکیده
منابع مشابه
The GARP complex is required for cellular sphingolipid homeostasis
Sphingolipids are abundant membrane components and important signaling molecules in eukaryotic cells. Their levels and localization are tightly regulated. However, the mechanisms underlying this regulation remain largely unknown. In this study, we identify the Golgi-associated retrograde protein (GARP) complex, which functions in endosome-to-Golgi retrograde vesicular transport, as a critical p...
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Epidermal hyperproliferation and inflammation are hallmarks of the human condition psoriasis. Here, we report that a zebrafish line with a mutation in the cargo adaptor protein Clint1 exhibits psoriasis-like phenotypes including epithelial hyperproliferation and leukocyte infiltration. Clint1 is an ENTH domain-containing protein that binds SNARE proteins and functions in vesicle trafficking; ho...
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Epidermal homeostasis under normal and healing conditions are critical for the physical and functional maintenance of the skin barrier. It requires a proper balance between keratinocyte proliferation and differentiation under genetic and epigenetic regulations. Here we show that mice carrying a hypomorphic mutation of the histone methyltransferase Ash1l [(absent, small, or homeotic)-like (Droso...
متن کاملPLATELETS AND THROMBOPOIESIS The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet -granule biogenesis
1Department of Biochemistry, University of Toronto, Toronto, ON; 2Program in Cell Biology, The Hospital for Sick Children, Toronto, ON; 3Department of Pediatrics, Neonatology Section, The Brody School of Medicine at East Carolina University, Greenville, NC; 4Departments of Neuroscience and Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX; 5Departments of Biochemistry & ...
متن کاملThe VPS33B-binding protein VPS16B is required in megakaryocyte and platelet α-granule biogenesis.
Patients with platelet α or dense δ-granule defects have bleeding problems. Although several proteins are known to be required for δ-granule development, less is known about α-granule biogenesis. Our previous work showed that the BEACH protein NBEAL2 and the Sec1/Munc18 protein VPS33B are required for α-granule biogenesis. Using a yeast two-hybrid screen, mass spectrometry, coimmunoprecipitatio...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2017
ISSN: 0022-202X
DOI: 10.1016/j.jid.2017.02.423